MCCQENephrology
Acute Kidney Injury: MCCQE Notes
Pre-renal, renal, post-renal — and an ultrasound plus a urinalysis will usually tell you which.
5 min readTopic Note
Revision notes
Structured the way you revise — mechanism, discriminators, first-line management, and the details that separate the right answer from the plausible one.
30 notes
MCCQENephrology
Hyponatraemia: A Working Approach — MCCQE Notes
Volume status plus urine sodium and osmolality gets you to the cause, and the rate of correction is what keeps the patient safe.
6 min readTopic Note
MRCP Part 2Nephrology
Polyuria: MRCP Part 2 Notes
Large urine volumes with a short differential — sort them into osmotic, water diuresis and drug causes.
3 min readTopic Note
MRCP Part 2Nephrology
Plasma Exchange (Plasmapheresis): MRCP Part 2 Notes
Removing pathogenic antibodies and immune complexes from plasma — key in anti-GBM disease, TTP and severe vasculitis.
4 min readTopic Note
MRCP Part 2Nephrology
Peritoneal Dialysis: MRCP Part 2 Notes
Home dialysis using the peritoneum as a membrane — with peritonitis as its defining complication.
4 min readTopic Note
MRCP Part 2Nephrology
Renal Papillary Necrosis: MRCP Part 2 Notes
Ischaemic death of the renal papillae — think analgesic nephropathy, diabetes and sickle cell disease.
3 min readTopic Note
MRCP Part 2Nephrology
Contrast-Induced Nephropathy: MRCP Part 2 Notes
An acute kidney injury a few days after iodinated contrast — largely preventable with hydration and risk-factor control.
3 min readTopic Note
MRCP Part 2Nephrology
Nephrotic Syndrome Complications: MRCP Part 2
Heavy urinary protein loss brings predictable complications — thrombosis, infection and hyperlipidaemia chief among them.
4 min readTopic Note
MRCP Part 2Nephrology
Membranoproliferative GN (MPGN): MRCP Part 2 Notes
A mixed nephritic-nephrotic glomerulonephritis with 'tram-track' basement membranes and low complement — think hepatitis C and complement dysregulation.
4 min readTopic Note
MRCP Part 2Nephrology
Measuring Clearance, Renal Blood Flow & GFR: MRCP
The physiology of clearance — inulin for GFR, PAH for renal plasma flow, and why creatinine clearance overestimates GFR.
4 min readTopic Note
MRCP Part 2Nephrology
IgA Nephropathy (Berger Disease): MRCP Part 2
The world's commonest glomerulonephritis — visible haematuria a day or two after an upper respiratory infection.
4 min readTopic Note
MRCP Part 2Nephrology
Hypokalaemia: MRCP Part 2 Notes
Low potassium sorted by whether it comes with alkalosis or acidosis — plus the classic U-wave ECG and safe replacement.
4 min readTopic Note
MRCP Part 2Nephrology
Hydronephrosis: MRCP Part 2 Notes
Dilatation of the renal pelvis and calyces from obstruction — with useful mnemonics for the unilateral and bilateral causes.
3 min readTopic Note
MRCP Part 2Nephrology
HIV-Associated Nephropathy (HIVAN): MRCP Part 2
A collapsing FSGS of advanced HIV — heavy proteinuria, large echogenic kidneys and rapid progression, best treated with antiretrovirals.
3 min readTopic Note
MRCP Part 2Nephrology
Haemolytic Uraemic Syndrome (HUS): MRCP Part 2
A thrombotic microangiopathy with a classic triad — usually following Shiga-toxin E. coli, occasionally from complement dysregulation.
5 min readTopic Note
MRCP Part 2Nephrology
Glomerulonephritides Overview: MRCP Part 2 Notes
A framework for the glomerular diseases — splitting them along the nephritic-to-nephrotic spectrum.
4 min readTopic Note
MRCP Part 2Nephrology
Fluid Therapy in Adults: MRCP Part 2 Notes
The NICE framework for prescribing IV fluids — resuscitation, routine maintenance, replacement, redistribution and reassessment.
4 min readTopic Note
MRCP Part 2Nephrology
Fanconi Syndrome: MRCP Part 2 Notes
Generalised proximal tubular failure — leaking glucose, amino acids, phosphate and bicarbonate into the urine.
4 min readTopic Note
MRCP Part 2Nephrology
Erectile Dysfunction: MRCP Part 2 Notes
Often the first warning sign of cardiovascular disease — with a useful organic-versus-psychogenic split guiding assessment.
4 min readTopic Note
MRCP Part 2Nephrology
Diabetes Insipidus: MRCP Part 2 Notes
Polyuria from ADH deficiency (cranial) or ADH resistance (nephrogenic) — distinguished by the water deprivation test.
5 min readTopic Note
MRCP Part 2Nephrology
Cystinuria: MRCP Part 2 Notes
An inherited defect in dibasic amino-acid reabsorption causing recurrent, poorly soluble cystine stones from a young age.
3 min readTopic Note
MRCP Part 2Nephrology
Chronic Prostatitis: MRCP Part 2 Notes
Persistent pelvic pain and urinary symptoms — most cases are non-bacterial chronic pelvic pain syndrome rather than infection.
3 min readTopic Note
MRCP Part 2Nephrology
CKD Anaemia: MRCP Part 2 Notes
A normochromic normocytic anaemia driven by erythropoietin deficiency — correct iron first, then use ESAs to a modest haemoglobin target.
4 min readTopic Note
MRCP Part 2Nephrology
ARPKD: MRCP Part 2 Notes
The childhood form of polycystic kidney disease — presenting antenatally or in infancy, with congenital hepatic fibrosis.
3 min readTopic Note
MRCP Part 2Nephrology
Anti-GBM Disease (Goodpasture): MRCP Part 2 Notes
A pulmonary-renal syndrome from antibodies against type IV collagen — rapidly progressive glomerulonephritis with lung haemorrhage.
5 min readTopic Note
MRCP Part 2Nephrology
The Anion Gap: MRCP Part 2 Notes
A simple calculation that splits metabolic acidosis into raised-gap and normal-gap causes — and points you to the diagnosis.
4 min readTopic Note
MRCP Part 2Nephrology
Amyloidosis: MRCP Part 2 Notes
Extracellular deposition of misfolded protein causing nephrotic syndrome, cardiac and multi-system disease — diagnosed by Congo red staining.
5 min readTopic Note
MRCP Part 2Nephrology
TINU Syndrome: MRCP Part 2 Notes
A rare syndrome combining acute interstitial nephritis with anterior uveitis, classically in young women.
3 min readTopic Note
MRCP Part 2Nephrology
Acute Interstitial Nephritis: MRCP Part 2 Notes
An immune-mediated cause of acute kidney injury — usually drug-induced — with eosinophilia, sterile pyuria and white cell casts.
5 min readTopic Note
MRCP Part 2Nephrology
Membranous Nephropathy: MRCP Part 2 Essentials
The commonest cause of nephrotic syndrome in older Caucasian adults — with a signature anti-PLA2R antibody and subepithelial deposits.
6 min readTopic Note